Louisville vs. Pittsburgh Prediction: Picks, Live Odds & Moneyline – October 14, 2023

Matt Rooney

Oct 14, 2023

A pair of ACC teams square off when the No. 14 Louisville Cardinals (6-0) face off against the Pittsburgh Panthers (1-4) on Saturday, October 14, 2023 at Acrisure Stadium. The Cardinals are favored by 7 points. The over/under is 45 in the outing.

Louisville vs. Pittsburgh Favorite, Moneyline, Total

Spread Favorite: Cardinals (-7)

Moneyline: Cardinals (-290), Panthers (+235)

Total: 45 points

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How to Watch Louisville vs. Pittsburgh

When: Saturday, October 14, 2023 at 6:30 PM ET

Location: Acrisure Stadium in Pittsburgh, Pennsylvania

TV: CW

Cardinals 2023 Stats & Rankings

Stat	Average (Total)	Rank
Pass yards	275 (1650)	36
Rush yards	192.7 (1156)	28
Points scored	36.3 (218)	16
Pass yards against	224.2 (1345)	65
Rush yards against	98.8 (593)	18
Points allowed	17.7 (106)	22

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Louisville 2023 Betting Info

The Cardinals have put together a 3-2-1 record against the spread this season.

Louisville has a 2-2 record against the spread in games it was favored by 7 points or more this season.

The Cardinals and their opponent have combined to hit the over three out of six times this season.

The average total in Cardinals games this season is 8.2 more points than the over/under of 45 in this game.

The Cardinals are 2-0-1 against the spread and 3-0 overall over their past three contests.

In two of those three games, the final combined score has gone over the set total.

The Panthers’ last three outings have ended with an average of 45.8 points scored. That’s 0.8 more points than this contest’s over/under.

Cardinals Home/Away Splits (2022)

	Overall	Home	Away
Point Total AVG	52.5	53.6	51.3
Implied Total AVG	29.2	29.4	29
ATS Record	8-5-0	6-1-0	2-4-0
Over/Under Record	4-9-0	2-5-0	2-4-0
Moneyline Favorite Record	5-2	5-0	0-2
Moneyline Underdog Record	3-3	1-1	2-2

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Louisville’s Offense vs. Pittsburgh’s Defense (2023)

The Cardinals are ranked 11th in the FBS in yards per pass (9.8), and will be up against the Panthers’ No. 111-ranked defense in that category (8.3).

The Cardinals have the 19th-ranked offense in the FBS (36.3 points per game), and will be facing the Panthers’ 72nd-ranked defense (26 ppg).

Louisville converts 38.7% of its third-down plays (74th in college football). Pittsburgh’s defense gives up third-down conversions at a 35.8% clip (47th).

Panthers 2023 Stats & Rankings

Stat	Average (Total)	Rank
Pass yards	192.6 (963)	109
Rush yards	116.2 (581)	112
Points scored	23.4 (117)	113
Pass yards against	173.2 (866)	16
Rush yards against	128.4 (642)	52
Points allowed	26 (130)	72

Pittsburgh 2023 Betting Info

The Panthers have posted one win against the spread this season.

Louisville is 2-2 against the spread when favored by 7 points or more this season.

This year, four of the Panthers’ five games have gone over the point total.

The average over/under the Cardinals have had set in games this year is 8.2 more points than this outing’s point total.

The Cardinals have covered the spread twice in their past three matchups while putting up a 3-0 record straight-up in those games.

The final combined score of the last three Pittsburgh games has surpassed the set total two times.

The Panthers’ past three games have ended with an average of 45.8 points scored. That’s 0.8 more points than this contest’s over/under.

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Panthers Home/Away Splits (2022)

	Overall	Home	Away
Point Total AVG	51.2	51.1	51.3
Implied Total AVG	30.5	32.1	28.5
ATS Record	6-7-0	2-5-0	4-2-0
Over/Under Record	8-4-1	4-2-1	4-2-0
Moneyline Favorite Record	8-1	5-1	3-0
Moneyline Underdog Record	1-3	0-1	1-2

Pittsburgh’s Offense vs. Louisville’s Defense (2023)

The Cardinals concede 323 yards per game (23rd-fewest in college football), and the Panthers pick up 308.8 per game to rank 122nd.

Louisville allows 98.8 rushing yards per game (18th in the FBS). Pittsburgh’s running game ranks 112th in college football (116.2).

The Cardinals defense ranks 23rd on a per-carry basis, giving up 3.2 yards per rushing attempt. The Panthers average 3.6 yards per carry (107th in the FBS).

Louisville has the 22nd-ranked scoring defense (17.7 points per game). Pittsburgh’s 100th-ranked scoring offense averages 23.4 points per game.

Louisville vs. Pittsburgh Prediction and Pick

Our prediction for Louisville vs. Pittsburgh sees the Cardinals (-290 on the moneyline) as the pick to win. Based on our analysis of the historical stats for this matchup, we pick the over at 45 points.

How to Bet on Louisville vs. Pittsburgh

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Or before you bet, why not check out our guide to betting on college football which breaks down how to bet the moneyline, and over/under totals above.

And finally, make sure college football betting is legal in your state by staying up to date with our guide.

For more college football betting news, check out our free college football picks, best bets, and predictions.

written by

Matt Rooney

Matt is from the Chicagoland area and has been working in Chicago sports since 2015 with stops at WGN Radio, the Chicago Blackhawks, Stadium, and NBC Sports Chicago prior to landing at Betsperts. Matt covers just about everything for Betsperts and Bleacher Nation but focuses on the NHL and college football.

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